Monday, May 18, 2015

What is the formula for calculating number of air changes in an area?

Number of air changes/hour in an area is:- 

                   = Total Room Airflow In CFM x 60
                      Total Volume of room in cubic feet

For calculating Total Room Airflow in CFM, first calculate air flow of individual filter. 

Formula is given below.

Air flow (in cfm) = Avg.air velocity in feet/Minute x Effective area of filter                                                  
Then find Total air flow. The Formula is:-
Total Air flow = Sum of air flow of individual filter.

Air flow Velocity can be measured with the help of Anemometer.

What is the formula for calculating number of air changes in an area?

Number of air changes/hour in an area is

                   = Total Room Airflow In CFM x 60
                    Total Volume of room in cubic feet
For calculating Total Room Airflow in CFM, first calculate air flow of individual filter. Formula is given below.

Air flow (in cfm) = Avg.air velocity in feet/Minute x Effective area of filter                                                  

Then find Total air flow. Formula is
Total Air flow = Sum of air flow of individual filter.

Air flow Velocity can be measured with the help of Anemometer.

What is the formula for calculating number of air changes in an area?

Number of air changes/hour in an area is

                   = Total Room Airflow In CFM x 60
                    Total Volume of room in cubic feet
For calculating Total Room Airflow in CFM, first calculate air flow of individual filter. Formula is given below.

Air flow (in cfm) = Avg.air velocity in feet/Minute x Effective area of filter                                                  

Then find Total air flow. Formula is
Total Air flow = Sum of air flow of individual filter.

Air flow Velocity can be measured with the help of Anemometer.

What is the formula for calculating number of air changes in an area?

Number of air changes/hour in an area is

                   = Total Room Airflow In CFM x 60
                    Total Volume of room in cubic feet
For calculating Total Room Airflow in CFM, first calculate air flow of individual filter. Formula is given below.

Air flow (in cfm) = Avg.air velocity in feet/Minute x Effective area of filter                                                

Then find Total air flow. Formula is
Total Air flow = Sum of air flow of individual filter.

Air flow Velocity can be measured with the help of Anemometer.

What is the formula


Wednesday, May 13, 2015

What is the purpose of stress testing in stability studies?

Stress testing of the drug substance can help identify the likely degradation products, which can in turn help establish the degradation pathways and the intrinsic stability of the molecule and validate the stability indicating power of the analytical procedures used. The nature of the stress testing will depend on the individual drug substance and the type of drug product involved.

What countries comes under climatic zone ivb?

Brazil, Cuba, China, Brunei, Cambodia, Indonesia, Malaysia, Myanmar, Philippines, Singapore, Thailand

According to WHO guidelines what is the storage condition of climatic zone iva and zone ivb?

Zone IV a: 30°C and 65% RH (hot and humid countries)
Zone IV b: 30°C and 75% RH (hot and very humid countries)

Monday, May 11, 2015

Forced degradation( stress testing ) & accelerated stability testing are same?

Forced degradation and stress testing are not same. Stress testing is likely to be carried out on a single batch of the drug substance. The testing should include the effect of temperatures (in 10°C increments (e.g., 50°C, 60°C) above that for accelerated testing), humidity (e.g., 75 percent relative humidity or greater) where appropriate, oxidation, and photolysis on the drug substance. The testing should also evaluate the susceptibility of the drug substance to hydrolysis across a wide range of pH values when in solution or suspension. Photo stability testing should be an integral part of stress testing.