Number of air changes/hour in an area is:- 
                   = Total Room Airflow In CFM x 60
                      Total Volume of room in cubic feet
For calculating Total Room Airflow in CFM, first calculate air flow of individual filter. 
Formula is given below.
Air flow (in cfm) = Avg.air velocity in feet/Minute x Effective area of filter                                                  
Then find Total air flow. The Formula is:-
Total Air flow = Sum of air flow of individual filter.
Air flow Velocity can be measured with the help of Anemometer.