Wednesday, March 11, 2015

Why some medicine come in capsule form?

  Some medications come in capsule form, because the nature of the substance makes it difficult or impossible to manufacture in a tablet form. Creating a tablet requires finding a binding material that allows the medication to be formed into a solid shape but that does not affect its chemical composition nor its bio-availability. For example, the typical aspirin tablet is held together mostly by corn starch.

  Some medications come in capsule form, because many consumers have a distinct preference for capsules. Many consumers perceive capsules as easier to swallow. Some consumers perceive capsules as more effective.

   An interesting example of the preference for capsules is provided by a study ("Effect of Shape of Medication in Treatment of Anxiety States") published in 1972 in the British Journal of Psychiatry by psychiatrist M. Z. Hussain, who found that patients being treated for anxiety responded better to treatment with the same drug (chlordiazepoxide) in capsule form rather than tablet form. There is no known medical reason for this, but its psychological significance is compelling. Capsules have been the required form for most clinical trials of psychiatric medications since 1972.
  Also some reason in capsule form because:-
       1. The nature of chemical substance. 
       2. Rapid bio availability rather than tablet.
       3. Easy to swallow for older and child patient. 
       4. Easy to manufacture where tablet need to more step.


Difference between relative humidity and humidity.

This is very important thing for the pharmaceuticals also any other organization, so need to know difference between this..

       "Humidity" and "Relative Humidity" are not the same thing. Humidity means amount of water vapor present in air with respect to total amount of air.         Relative Humidity is the amount of moisture in the air 'relative' to the temperature (i.e. relative humidity is the amount of moisture in the air compared to what the air can "hold" at that temperature. When the air can't "hold" all the moisture, then it condenses as dew).


          The relative humidity is a measure of the amount of water vapor in the air (at a specific temperature) compared to the maximum amount of water vapor air could hold at that temperature, and is given as a percentage value. Relative humidity depends on the temperature of the air.

Wednesday, January 14, 2015

Seek for Quality Control Department...

FnF Pharmaceuticals Ltd.
Rautail, Nagarbathan, Jhenidah.

Who are interested to doing job in this Organization, send your updated CV attached with recent passport size photograph bellow this contact address:-

Working Station: Quality Control ( Factory ),  Jhenidah

Prefer: Candidates in this region.( Khulna Division ) 

email: lelinfnfpharma@gmail.com
P.N: 01740601602/ 01925684674   

Sunday, January 4, 2015

Some common excipient, those are mostly used in pharmaceutical preparation.

Binders: To add cohesiveness to powder providing necessary bonding  to form granules
        Ex: CMC, Starch paste, Povidone, Avicel.
     N.B: Some binders soluble in non aq. system(like ethanol)for moisture sensitive drugs(ranitidine)

 Diluent: Increase physical size of the tablet in order to compressed the tablet.
              Ex: Starch, Lactose

Disintegrant: Agents added prior to granulation or during lubrication step or both process step
               Ex: Maize Starch, Lactose, Micro Crystalline Cellulose

Lubricants: Reduce the friction between the granules and die wall during compression and ejection
Ex: Water insoluble lubricant Mg,Na,Ca- stearate, Talk, Water soluble lubricant Na-acetate, Na-lauryl sulphate
     
   N.B: Mg-stearate boundary type lubricant form a coat around the individuals particles (Granules) which  remain  more or less intact during compression. Water insoluble lubricant More effective  as they used in low concentration, Water soluble lubricant must be used when the tablet must completely water soluble like effervescent tablet. Powder lubricant not used prior to wet granulation

Anti-adherent: Prevent sticking granules to the punch and to a laser extent to die wall
              Ex: Talk, Aerosil/Cabosil

Glidants: Improves flow characteristics  of the granules
              Ex: Talk , Starch, Aerosil

Colarant: To identify similar looking products within products line, Minimize possibility of mixture during manufacture.
           Ex: Dyes (water soluble), lakes (formed by adsorption of H2O soluble dyes on a hydrous oxide Al(OH)3 which result H2O insoluble dye)
             N.B: H2O soluble dyes are dissolve in the granulation system which                   assure uniform distribution

Adsorbent: Capable of holding up to 50% of its weight of water.
              Ex: Syloid, cab-o-sil/aerosol, Bentonite, Kaolin, Mg-silicate  

Choice of excepients: Depends on tablet type, desired characteristics, manufacturing process used and physical and chemical compatibility with API

Avicel: Micro-crystalline cellulose.
TYPE:
Grade
Size Micro meter
LOD
PH-101
50
4%
PH-102
90
4%
PH-105
20
3%
PH-200
180
4%
PH-302
90
4%
N.B: Generally PH-101 are mostly used in Wet Granulation, PH-102 are used in Direct Compression 
In expensive filler:
Ex: Encompress: Dibasic-Ca-phosphate, 
      Compactrol/Terra alba: Dihydrate Ca-sulphate
      Tritab: Tri-Ca-phosphate


Cellulose: Special grade of microcrystalline cellulose, have superior compressibility and high dilution potential for this properties good for formulation of small size tablets with high content of API.