Binders: To add cohesiveness to powder providing necessary
bonding to form granules
Ex: CMC, Starch paste, Povidone, Avicel.
N.B: Some binders soluble in non aq. system(like ethanol)for moisture sensitive drugs(ranitidine)
Ex: Starch, Lactose
Disintegrant: Agents added prior to granulation or during
lubrication step or both process step
Ex: Maize Starch, Lactose, Micro Crystalline Cellulose
Lubricants: Reduce the friction between the granules and die
wall during compression and ejection
Ex: Water insoluble lubricant Mg,Na,Ca-
stearate, Talk, Water soluble lubricant Na-acetate, Na-lauryl sulphate
N.B: Mg-stearate boundary type lubricant
form a coat around the individuals particles (Granules) which remain more or less intact during compression. Water
insoluble lubricant More effective as they used in low
concentration, Water soluble lubricant must be used when the tablet must completely water soluble like effervescent tablet. Powder
lubricant not used prior to wet granulation
Anti-adherent: Prevent sticking granules to the punch and to
a laser extent to die wall
Ex:
Talk, Aerosil/Cabosil
Glidants: Improves flow characteristics of the
granules
Ex: Talk , Starch, Aerosil
Colarant: To identify similar looking products
within products line, Minimize possibility of mixture during manufacture.
Ex: Dyes (water
soluble), lakes (formed by adsorption of H2O soluble dyes on a hydrous oxide
Al(OH)3 which result H2O insoluble dye)
Adsorbent: Capable of holding up to 50% of its weight of
water.
Ex: Syloid, cab-o-sil/aerosol, Bentonite,
Kaolin, Mg-silicate
Choice of excepients: Depends on tablet type, desired
characteristics, manufacturing process used and physical and chemical
compatibility with API
Avicel: Micro-crystalline cellulose.
TYPE:
Grade
|
Size Micro meter
|
LOD
|
PH-101
|
50
|
4%
|
PH-102
|
90
|
4%
|
PH-105
|
20
|
3%
|
PH-200
|
180
|
4%
|
PH-302
|
90
|
4%
|
N.B: Generally PH-101 are mostly used in Wet Granulation, PH-102 are used in Direct Compression
In expensive filler:
Ex: Encompress: Dibasic-Ca-phosphate,
Compactrol/Terra
alba: Dihydrate Ca-sulphate
Tritab:
Tri-Ca-phosphate
Cellulose: Special grade of microcrystalline cellulose, have
superior compressibility and high dilution potential for this properties good
for formulation of small size tablets with high content of API.
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